Decellularized vascularized bone grafts as therapeutic solution for bone reconstruction: A mechanical evaluation.

ABSTRACT:

Introduction

Large bone defects are challenging for surgeons. Available reimplanted bone substitutes can't properly restore optimal function along and long term osteointegration of the bone graft. Bone substitute based on the perfusion-decellularization technique seem to be interesting in order to overcome these limitations. We present here an evaluation of the biomechanics of the bones thus obtained.

Material and methods

Two decellularization protocols were chosen for this study. One using Sodium Dodecyl Sulfate (SDS) (D1) and one using NaOH and H2O2 (D2). The decellularization was performed on porcine forearms. We then carried out compression, three-point bending, indentation and screw pull-out tests on each sample. Once these tests were completed, we compared the results

SUBMITTER: Heller U 

PROVIDER: S-EPMC9838862 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature