Effect of ozone on allergic airway inflammation.

ABSTRACT:

Background

Exposure to ozone (O₃) is associated with increased risk of exacerbations of asthma, but the underlying mechanisms are not well studied.

Objective

We sought to determine whether O₃ exposure would enhance airway inflammatory responses to allergen and the GSTM1-null genotype would modulate this enhancement.

Methods

In a crossover design, 10 asthmatic participants (5 with GSTM1-null genotype) who had specific sensitization to Dermatophagoides pteronyssinus (DP) were exposed to 160 ppb O₃ or filtered air (FA) control for 4 hours on 2 separate days at least 3 weeks apart. At 20 hours after exposure, endobronchial challenge with DP allergen, and sham normal saline (NS) instillation, were performed in separate bronchi. Six h

SUBMITTER: Arjomandi M 

PROVIDER: S-EPMC9838882 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature