The ERAD system is restricted by elevated ceramides.
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ABSTRACT:
SUBMITTER: Hwang J
PROVIDER: S-EPMC9839339 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
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The ERAD system is restricted by elevated ceramides.
Hwang Jiwon J Peterson Brian G BG Knupp Jeffrey J Baldridge Ryan D RD
Science advances 20230113 2
Misfolded proteins in the endoplasmic reticulum (ER) are removed through a process known as ER-associated degradation (ERAD). ERAD occurs through an integral membrane protein quality control system that recognizes substrates, retrotranslocates the substrates across the membrane, and ubiquitinates and extracts the substrates from the membrane for degradation at the cytosolic proteasome. While ERAD systems are known to regulate lipid biosynthetic enzymes, the regulation of ERAD systems by the lipi ...[more]
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