Bone morphogenetic protein 10: a novel risk marker of ischaemic stroke in patients with atrial fibrillation.

ABSTRACT:

Aims

Biomarkers specifically related to atrial tissue may increase the understanding of the pathophysiology of atrial fibrillation (AF) and further improve risk prediction in this setting. Bone morphogenetic protein 10 (BMP10) is a protein expressed in the atrial myocardium. We evaluated the association between BMP10 and the risk of ischaemic stroke and other cardiovascular events in large cohorts of patients with AF, treated with and without oral anticoagulation (OAC).

Methods and results

BMP10 was measured in plasma samples collected at randomisation in patients with AF without OAC in the ACTIVE A and AVERROES trials (n = 2974), and with OAC in the ARISTOTLE trial (n = 13 079). BMP10 was analysed with a prototype Elecsys immunoassay. Associations with outcomes were evaluat

SUBMITTER: Hijazi Z 

PROVIDER: S-EPMC9839419 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature