Circulating endocannabinoids and psychological outcomes in women with PTSD.

ABSTRACT:

Background

Recent research has attempted to elucidate the relationship between blood-based biomarkers (e.g., endocannabinoids; eCBs: including N-arachidonoylethanolamine [AEA] and 2-arachidonoylglycerol [2-AG]) and mental health outcomes in psychiatric populations such as posttraumatic stress disorder (PTSD). Prior research suggests that adults with PTSD may have altered circulating eCB tone and a blunted mobilization of eCBs (particularly 2-AG) in response to stress (e.g., aerobic exercise), although our understanding has been limited in part due to heterogenous samples and small sample sizes.

Methods

A subset of data was pooled from five studies in which women with and without PTSD (N = 98) completed questionnaires related to mood states and a blood draw prior to and follo

SUBMITTER: Botsford C 

PROVIDER: S-EPMC9839585 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature