Typical and atypical neural mechanisms support spoken word processing in Angelman syndrome.

ABSTRACT: Angelman syndrome (AS) is known to affect expressive and receptive communication abilities. This study examined individual differences in neural mechanisms underlying speech processing in children with AS (n = 24, M age = 10.01 years) and typical development (n = 30, M age = 10.82 years) using auditory event-related potentials during passive listening to common English words and novel pseudowords. A group of adults with AS (n = 7, M = 31.78 years) provided data about the upper developmental range. The typically developing group demonstrated the expected more negative amplitudes in response to words than pseudowords within 250-500 ms after stimulus onset at the left temporal scalp region. Children and adults with AS exhibited a similar left-lateralized pattern of word-pseudoword differentia

SUBMITTER: Key AP 

PROVIDER: S-EPMC9839587 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature