Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development.
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ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC9839616 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
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Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development.
Wang Xiaochen X He Qifeng Q Zhou Chuanli C Xu Yueyuan Y Liu Danhui D Fujiwara Naoto N Kubota Naoto N Click Arielle A Henderson Polly P Vancil Janiece J Marquez Cesia Ammi CA Gunasekaran Ganesh G Schwartz Myron E ME Tabrizian Parissa P Sarpel Umut U Fiel Maria Isabel MI Diao Yarui Y Sun Beicheng B Hoshida Yujin Y Liang Shuang S Zhong Zhenyu Z
Immunity 20221214 1
Obesity-induced chronic liver inflammation is a hallmark of nonalcoholic steatohepatitis (NASH)-an aggressive form of nonalcoholic fatty liver disease. However, it remains unclear how such a low-grade, yet persistent, inflammation is sustained in the liver. Here, we show that the macrophage phagocytic receptor TREM2, induced by hepatocyte-derived sphingosine-1-phosphate, was required for efferocytosis of lipid-laden apoptotic hepatocytes and thereby maintained liver immune homeostasis. However, ...[more]
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