Female donor hearts can improve survival for male pediatric heart transplant recipients.

ABSTRACT:

Background

Both gender- and weight-matching between donor and recipient are thought to impact survival in pediatric heart transplantation, with clinical dogma holding that male donor hearts and "ideal" weight-matching yield superior survival. The composite impacts of gender and weight on post-transplant survival (PTS) are understudied.

Methods

All pediatric (age <18) heart recipients between 1989 and 2021 with the complete recipient and donor gender and weight data were identified in the United Network for Organ Sharing database. Patients were grouped by recipient-donor gender (M & F) and donor-to-recipient weight ratio (DRWR; undersized [<0.8], ideal-sized [0.8-1.5], oversized [>1.5]).

Results

A total of 10 697 patients were identified. Among male recipients, PTS was

SUBMITTER: Greenberg JW 

PROVIDER: S-EPMC9839626 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature