A behavioral timing intervention upregulates striatal serotonergic markers and reduces impulsive action in adult male mice.

ABSTRACT: Many studies support the hypothesis that time-based interventions reduce impulsive behavior in rodents. However, few studies have directly assessed 1) how such interventions affect impulsive action rather than impulsive choice, 2) if intervention effects differ by sex, and 3) how time-based interventions affect neurochemistry in regions mediating decision-making and reward. Thus, we assessed how a fixed-interval (FI) intervention initiated during late adolescence and extending into adulthood affected dopaminergic and serotonergic analytes in the frontal cortex and striatum and subsequent impulsive action in adult male and female mice. Beginning on postnatal day (PND) 45, mice were either trained on a progressive series of FI schedules (FI 20, 40, & 60 s) or remained in the home cage. Follo

SUBMITTER: Eckard ML 

PROVIDER: S-EPMC9839656 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature