Betulinaldehyde exhibits effective anti-tumor effects in A549 cells by regulating intracellular autophagy.

ABSTRACT: It is of great significance to find new effective drugs for an adjuvant therapy targeting lung cancer to improve the survival rate and prognosis of patients with the disease. Previous studies have confirmed that certain Chinese herbal extracts have clear anti-tumor effects, and in our preliminary study, betulinaldehyde was screened for its potential anti-tumor effects. The current study thus aimed to confirm the anti-tumor effect of betulinaldehyde, using in vitro experiments to explore its underlying molecular mechanism. It was found that betulinaldehyde treatment significantly inhibited the viability, proliferation, and migration of A549 cells in a dose-dependent manner. In addition, betulinaldehyde inhibited the activation of Akt, MAPK, and STAT3 signaling pathways in A549 cells in a ti

SUBMITTER: Huang PH 

PROVIDER: S-EPMC9839726 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature