Autologous adipose-derived stromal vascular fraction and platelet concentrates for the treatment of complex perianal fistulas.

ABSTRACT:

Background

Complex perianal fistulas are a major challenge for modern surgery since 10-35% of patients have functional problems after treatment. Sphincter-saving techniques have a wide range of efficacy (10-80%). We hypothesised that autologous adipose-derived stromal vascular fraction in combination with platelet rich plasma is a new therapeutic strategy with enhanced cure and function preservation rates.

Methods

Adult patients with complex cryptoglandular perianal fistulas were treated with injection of autologous adipose-derived stromal vascular fraction in combination with platelet rich plasma around and inside the fistulous tract between May 2018 and April 2019 at the General and Emergency Surgery Operative Unit of the University Hospital "P. Giaccone" of Palermo. Fistu

SUBMITTER: Tutino R 

PROVIDER: S-EPMC9839808 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature