Multifunctional Superparticles for Magnetically Targeted NIR-II Imaging and Photodynamic Therapy.

ABSTRACT: Theranostics, the combination of diagnostics and therapies, has been considered as a promising strategy for clinical cancer treatment. Nonetheless, building a smart theranostic system with multifunction for different on-demand applications still remains elusive. Herein, an easy and user-friendly microemulsion based method is developed to modularly assemble upconversion nanoparticles (UCNPs) and Fe₃ O₄ nanoparticles together, forming multifunctional UCNPs/Fe₃ O₄ superparticles with highly integrated functionalities including the 808 nm excitation for real-time NIR-II imaging, magnetic targeting, and the upconversion luminescence upon 980 nm excitation for on-demand photodynamic therapy (PDT). With a magnet placed nearby the tumor, in vivo NIR-II i

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9839852 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature