Plasma MicroRNA Signature of Alcohol Consumption: The Rotterdam Study.

ABSTRACT:

Background

MicroRNAs (miRNAs) represent a class of noncoding RNAs that regulate gene expression and are implicated in the pathogenesis of different diseases. Alcohol consumption might affect the expression of miRNAs, which in turn could play a role in risk of diseases.

Objectives

We investigated whether plasma concentrations of miRNAs are altered by alcohol consumption. Given the existing evidence showing the link between alcohol and liver diseases, we further explored the extent to which these associations are mediated by miRNAs.

Methods

Profiling of plasma miRNAs was conducted using the HTG EdgeSeq miRNA Whole Transcriptome Assay in 1933 participants of the Rotterdam Study. Linear regression was implemented to explore the link between alcohol consumption (glasses/d)

SUBMITTER: Karabegovic I 

PROVIDER: S-EPMC9839997 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature