Molecular typing and prognostic model of lung adenocarcinoma based on cuprotosis-related lncRNAs.

ABSTRACT:

Background

Previous research has shown the heterogeneity of lung adenocarcinoma (LUAD) accounts for the different effects and prognoses of the same treatment. Cuprotosis is a newly discovered form of programmed cell death involved in the development of tumors. Therefore, it is important to study the long non-coding RNAs (lncRNAs) that regulate cuprotosis to identify molecular subtypes and predict survival of LUAD.

Methods

The expression profile, clinical, and mutation data of LUAD were downloaded from The Cancer Genome Atlas (TCGA), and the "ConsensusClusterPlus" package was used to cluster LUADs based on cuprotosis-related lncRNAs (CR-lncRNAs). The least absolute shrinkage and selection operator (LASSO) and multivariate Cox regression were used to construct a prognostic mod

SUBMITTER: Zheng M 

PROVIDER: S-EPMC9840007 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature