Correlation between oncogene integrator complex subunit 7 and a poor prognosis in lung adenocarcinoma.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) is one of the most common types of cancer worldwide with high incidence and mortality rates. The integrator complex subunit 7 (INTS7) encodes a subunit of the integrator complex that mediates small-nuclear ribonucleic acid (RNA) processing and has been shown to be associated with RNA polymerase II. However, the clinical significance of INTS7 in LUAD is still not clear and needs to be investigated.

Methods

The single-cell sequencing of a publicly available data set was conducted to compare the expression levels and percentages of INTS7 in lung malignant cells at different classifications and stages. Further, 33 cancer types from The Cancer Genome Atlas (TCGA) database were analyzed, protein-protein interaction (PPI) networks were construc

SUBMITTER: Li Z 

PROVIDER: S-EPMC9840021 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature