Characterization of driver mutations in Chinese non-small cell lung cancer patients using a novel targeted sequencing panel.

ABSTRACT:

Background

The identification of driver mutations has greatly promoted the precise diagnosis and treatment of non-small cell lung cancer (NSCLC), but there is lack of targeted sequencing panels specifically designed and applied to Chinese NSCLC patients. This study aimed to design and validate of a novel sequencing panel for comprehensive characterization of driver mutations in Chinese NSCLC patients, facilitating further exploration of downstream pathway alterations and therapeutic utility.

Methods

A novel target sequencing panel including 21 driver genes was designed and examined in a cohort of 260 Chinese NSCLC patients who underwent surgery in Peking Union Medical College Hospital (PUMCH). Genetic alterations were identified and further analyzed for driver mutations, dow

SUBMITTER: Zhao J 

PROVIDER: S-EPMC9840037 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature