Free radical induced degradation and computational studies of hydroxychloroquine in aqueous solution.

ABSTRACT: Hydroxychloroquine (HCQ) is a potential drug molecule for treating malaria. Recently it has also been tried as adjustment in Covid 19 therapy. Interaction of HCQ with free radicals is very important, which controls its stability in the environment where free radicals are generated unintentionally. In this report, we present detailed investigation on the reactions of hydrated electrons (e_aq ^-) and hydroxyl radical (^•OH) with HCQ in aqueous solution through electron pulse radiolysis technique and computational studies. The degradation of HCQ was found to be faster in the case of reaction with ^•OH radicals. However, the degradation could be substantially slowed down in the presence of antioxidants like ascorbic acid and gallic acid. This revealed th

SUBMITTER: Rath MC 

PROVIDER: S-EPMC9840095 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature