MAP7D2 reduces CD8⁺ cytotoxic T lymphocyte infiltration through MYH9-HMGB1 axis in colorectal cancer.

ABSTRACT: Immune checkpoint inhibitors (ICIs) represent a new paradigm in cancer immunotherapy, but can be largely restricted by the limited presence of CD8⁺ cytotoxic T lymphocytes (CTLs) in colorectal cancer (CRC) patients with microsatellite stable (MSS) tumors. Here, through next-generation sequencing, we identify microtubule-associated protein 7 domain 2 (MAP7D2) as an exploitable therapeutic maneuver to improve the efficacy of ICIs for MSS CRC therapy. In human CRC tissues, MAP7D2 expression is significantly increased in MSS CRC, and MAP7D2 adversely correlates with the presence of antitumor T lymphocytes. In vitro and in vivo experiments demonstrate that MAP7D2 knockdown significantly increases the infiltration of CD8⁺ CTLs, thereby inhibiting tumor progression and impro

SUBMITTER: Wu Q 

PROVIDER: S-EPMC9840115 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature