Identification of key pharmacological components and targets for Aidi injection in the treatment of pancreatic cancer by UPLC-MS, network pharmacology, and in vivo experiments.

ABSTRACT:

Background

Pancreatic cancer is one of the most lethal cancers worldwide. Aidi injection (ADI) is a representative antitumor medication based on Chinese herbal injection, but its antitumor mechanisms are still poorly understood.

Materials and methods

In this work, the subcutaneous xenograft model of human pancreatic cancer cell line Panc-1 was established in nude mice to investigate the anticancer effect of ADI in vivo. We then determined the components of ADI using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS) and explored the possible molecular mechanisms against pancreatic cancer using network pharmacology.

Results

In vivo experiments, the volume, weight, and degree of histological abnormalities of implanted tumors were significantly lo

SUBMITTER: Wang H 

PROVIDER: S-EPMC9840244 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature