Umbrella review of basket trials testing a drug in tumors with actionable genetic biomarkers.

ABSTRACT:

Background

The utilization of basket trials in oncology has gained popularity because of the drive for precision medicine and the increasing ease of genetically profiling tumors. However, it is unknown if this has translated into patient benefit, either through higher response rates because of precision treatment or because of increasing options for less-common tumor types that are less represented in oncology drug trials. We sought to characterize basket studies for oncology drugs targeting a genetic biomarker, determine the responses for various tumor types and genetic biomarkers, and test for correlation between the number of participants in each tumor basket and the incidence of the respective tumor.

Methods

We conducted a retrospective cross-sectional review of oncology

SUBMITTER: Haslam A 

PROVIDER: S-EPMC9840247 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature