Can circulating cell free DNA be a promising marker in ovarian cancer? - a genome-scale profiling study in a single institution.

ABSTRACT:

Background

Cell-free DNA (cfDNA) is emerging as a potential biomarker for the detection of ovarian cancer (OC). Recently, we reported a method based upon cfDNA whole-genome sequencing data including the nucleosome distribution (nucleosome footprinting NF), terminal signature sequence (motif), DNA fragmentation (fragment), and copy number variation (CNV).In the present study, we explored whether multiomics early screening technology in cfDNA can be applied for early screening of ovarian cancer.

Methods

Fifty-nine patients with OC and 100 healthy controls were included in this prospective study. Cell-free DNA was extracted from plasma and analyzed by low-pass whole-genome sequencing. Genomic features were obtained for all samples of the cohort, including copy number variation

SUBMITTER: Zhou H 

PROVIDER: S-EPMC9840311 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature