Inhibition of c-Jun in AgRP neurons increases stress-induced anxiety and colitis susceptibility.

ABSTRACT: Psychiatric disorders, such as anxiety, are associated with inflammatory bowel disease (IBD), however, the neural mechanisms regulating this comorbidity are unknown. Here, we show that hypothalamic agouti-related protein (AgRP) neuronal activity is suppressed under chronic restraint stress (CRS), a condition known to increase anxiety and colitis susceptibility. Consistently, chemogenic activation or inhibition of AgRP neurons reverses or mimics CRS-induced increase of anxiety-like behaviors and colitis susceptibility, respectively. Furthermore, CRS inhibits AgRP neuronal activity by suppressing the expression of c-Jun. Moreover, overexpression of c-Jun in these neurons protects against the CRS-induced effects, and knockdown of c-Jun in AgRP neurons (c-Jun^∆AgRP) promotes anxiety

SUBMITTER: Jiao F 

PROVIDER: S-EPMC9840628 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature