Anticholinergic Medications and Parent-Reported Anticholinergic Symptoms in Neurologically Impaired Children.

ABSTRACT:

Context

Children with severe neurological impairment and polypharmacy are exposed to anticholinergic (AC) medications that may have anticholinergic side effects, but this is understudied. Anticholinergic Cognitive Burden (ACB) scores measure total anticholinergic burden for a medication regimen, and scores ≥3 have been associated with increased morbidity and mortality in adults.

Objective

We assessed the relationship between ACB scores and parent-reported anticholinergic symptoms in children.

Methods

Cross-sectional study of patients one to 18 years-old with ICD-defined severe neurological impairment and polypharmacy. At routine clinical visits, total ACB scores were computed for all medications. Parent-reported AC symptoms (constipation, drowsiness, difficulty concen

SUBMITTER: Feinstein JA 

PROVIDER: S-EPMC9840664 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature