Ozone impairs endogenous compensatory responses in allergic asthma.

ABSTRACT: Asthma is a chronic inflammatory airway disease characterized by acute exacerbations triggered by inhaled allergens, respiratory infections, or air pollution. Ozone (O₃), a major component of air pollution, can damage the lung epithelium in healthy individuals. Despite this association, little is known about the effects of O₃ and its impact on chronic lung disease. Epidemiological data have demonstrated that elevations in ambient O₃ are associated with increased asthma exacerbations. To identify mechanisms by which O₃ exposure leads to asthma exacerbations, we developed a two-hit mouse model where mice were sensitized and challenged with three common allergens (dust mite, ragweed and Aspergillus fumigates, DRA) to induce allergic inflammation pri

SUBMITTER: Ho K 

PROVIDER: S-EPMC9840700 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature