Comprehensive genomic signature of pyroptosis-related genes and relevant characterization in hepatocellular carcinoma.

ABSTRACT:

Background

Currently, the most predominant type of liver cancer is hepatocellular carcinoma (HCC), which is also the fourth leading cause of cancer-related death in the global population. Pyroptosis is an emerging form of cell death that affects the prognosis of cancer patients by modulating tumor cell migration, proliferation and invasion. However, the evaluation of pyroptosis in the prognosis of HCC is still insufficient.

Methods

A total of 365 HCC patients from the TCGA-LIHC cohort were classified into two distinct subtypes using consensus clustering of pyroptosis-related genes (PRGs). Following univariate Cox analysis of differentially expressed genes between subtypes, we established a prognostic model (PRGs-score, PRGS) by LASSO Cox analysis. We further tested the predi

SUBMITTER: Wang S 

PROVIDER: S-EPMC9840857 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature