Oxygen-enhanced MRI and radiotherapy in patients with oropharyngeal squamous cell carcinoma.

ABSTRACT:

Background and purpose

This study aimed to assess the role of T1 mapping and oxygen-enhanced MRI in patients undergoing radical dose radiotherapy for HPV positive oropharyngeal cancer, which has not yet been examined in an OE-MRI study.

Materials and methods

Variable Flip Angle T1 maps were acquired on a 3T MRI scanner while patients (n = 12) breathed air and/or 100 % oxygen, before and after fraction 10 of the planned 30 fractions of chemoradiotherapy ('visit 1' and 'visit 2', respectively). The analysis aimed to assess to what extent (1) native R1 relates to patient outcome; (2) OE-MRI response relates to patient outcome; (3) changes in mean R1 before and after radiotherapy related to clinical outcome in patients with oropharyngeal squamous cell carcinoma.

Results

D

SUBMITTER: Bluemke E 

PROVIDER: S-EPMC9841018 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature