Intelligent microneedle patch with prolonged local release of hydrogen and magnesium ions for diabetic wound healing.

ABSTRACT: Diabetes mellitus, an epidemic with a rapidly increasing number of patients, always leads to delayed wound healing associated with consistent pro-inflammatory M1 polarization, decreased angiogenesis and increased reactive oxygen species (ROS) in the microenvironment. Herein, a poly (lactic-co-glycolic acid) (PLGA)-based microneedle patch loaded with magnesium hydride (MgH₂) (MN-MgH₂) is manufactured for defeating diabetic wounds. The application of microneedle patch contributes to the transdermal delivery and the prolonged release of MgH₂ that can generate hydrogen (H₂) and magnesium ions (Mg²⁺) after reaction with body fluids. The released H₂ reduces the production of ROS, transforming the pathological microenvironme

SUBMITTER: Wang P 

PROVIDER: S-EPMC9841127 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature