Intelligent microneedle patch with prolonged local release of hydrogen and magnesium ions for diabetic wound healing

ABSTRACT: Diabetes mellitus, an epidemic with a rapidly increasing number of patients, always leads to delayed wound healing associated with consistent pro-inflammatory M1 polarization, decreased angiogenesis and increased reactive oxygen species (ROS) in the microenvironment. Herein, a poly (lactic-co-glycolic acid) (PLGA)-based microneedle patch loaded with magnesium hydride (MgH2) (MN-MgH2) is manufactured for defeating diabetic wounds. The application of microneedle patch contributes to the transdermal delivery and the prolonged release of MgH2 that can generate hydrogen (H2) and magnesium ions (Mg2+) after reaction with body fluids. The released H2 reduces the production of ROS, transforming the pathological microenvironment induced by diabetes mellitus. Meanwhile, the released Mg2+ promotes the polarization of pro-healing M2 macrophages. Consequently, cell proliferation and migration are improved, and angiogenesis and tissue regeneration are enhanced. Such intelligent microneedle patch provides a novel way for accelerating wound healing through steadily preserving and releasing of H2 and Mg2+ locally and sustainably. Graphical abstract Intelligent microneedle patch with prolonged local release of hydrogen (H2) and magnesium ions (Mg2+) is developed for diabetic wound healing. The released H2 reduces the local reactive oxygen species (ROS), transforming the pathological microenvironment induced by diabetes mellitus. Meanwhile, the released Mg2+ promotes the polarization of pro-healing M2 macrophages, improves cell proliferation and migration, and enhances angiogenesis.Image 1 Highlights • Microneedle patch loaded with magnesium hydride (MN-MgH2) is manufactured for defeating diabetic wounds.• MN-MgH2 can sustainably release H2 to reduce reactive oxygen species.• MN-MgH2 can release Mg2+ to promote the polarization of pro-healing M2 macrophages.• MN-MgH2 can improve cell proliferation and migration and enhance angiogenesis.

SUBMITTER: Wang P 

PROVIDER: S-EPMC9841127 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature