Core-shell oxygen-releasing fibers for annulus fibrosus repair in the intervertebral disc of rats.

ABSTRACT: The repair of annulus fibrosus (AF) defect after discectomy in the intervertebral disc (IVD) has presented a challenge over the past decade. Hostile microenvironments in the IVD, including, compression and hypoxia, are critical issues that require special attention. Till date, little information is available on potential strategies to cope with the hypoxia dilemma in AF defect sites. In this study, perfluorotributylamine (PFTBA) core-shell fibers were fabricated by coaxial electrospinning to construct oxygen-releasing scaffold for promoting endogenous repair in the AF after discectomy. We demonstrated that PFTBA fibers (10% chitosan, chitosan: PCL, 1:6) could release oxygen for up to 144 ​h. The oxygen released from PFTBA fibers was found to protect annulus fibrosus stem cells (AFSCs) from

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC9841168 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature