Dysregulated systemic metabolism in a Down syndrome mouse model.

ABSTRACT:

Objective

Trisomy 21 is one of the most complex genetic perturbations compatible with postnatal survival. Dosage imbalance arising from the triplication of genes on human chromosome 21 (Hsa21) affects multiple organ systems. Much of Down syndrome (DS) research, however, has focused on addressing how aneuploidy dysregulates CNS function leading to cognitive deficit. Although obesity, diabetes, and associated sequelae such as fatty liver and dyslipidemia are well documented in the DS population, only limited studies have been conducted to determine how gene dosage imbalance affects whole-body metabolism. Here, we conduct a comprehensive and systematic analysis of key metabolic parameters across different physiological states in the Ts65Dn trisomic mouse model of DS.

Methods

Ts

SUBMITTER: Sarver DC 

PROVIDER: S-EPMC9841171 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature