Reversal of rocuronium-induced intense neuromuscular blockade by sugammadex in Korean children: A pharmacokinetic and pharmacodynamic analysis.

ABSTRACT: Sugammadex, a selective antagonist of steroidal non-depolarizing neuromuscular blocking agents, has been used in children in limited circumstances. However, neither pharmacokinetics (PKs) nor recovery profile of sugammadex for intense neuromuscular blockade reversal in children have been reported. This prospective study aimed to obtain a PK model of sugammadex and evaluate its efficacy and safety for intense neuromuscular blockade reversal in children. Forty children (age, 2-17 years) who underwent surgery that required early neuromuscular blockade reversal were enrolled. After neuromuscular blockade with 1 mg∙kg^-1 of rocuronium, sugammadex (2, 4, and 8 mg∙kg^-1 ) or a conventional dose of neostigmine (0.03 mg∙kg^-1 ) was administered randomly after confirmat

SUBMITTER: Ji SH 

PROVIDER: S-EPMC9841294 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature