Single-Chain Polymer Nanoparticles Targeting the Ookinete Stage of Malaria Parasites.

ABSTRACT: Malaria is an infectious disease transmitted by mosquitos, whose control is hampered by drug resistance evolution in the causing agent, protist parasites of the genus Plasmodium, as well as by the resistance of the mosquito to insecticides. New approaches to fight this disease are, therefore, needed. Research into targeted drug delivery is expanding as this strategy increases treatment efficacies. Alternatively, targeting the parasite in humans, here we use single-chain polymer nanoparticles (SCNPs) to target the parasite at the ookinete stage, which is one of the stages in the mosquito. This nanocarrier system provides uniquely sized and monodispersed particles of 5-20 nm, via thiol-Michael addition. The conjugation of succinic anhydride to the SCNP surface provides negative surfac

SUBMITTER: Hamelmann NM 

PROVIDER: S-EPMC9841520 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature