Muc16 depletion diminishes KRAS-induced tumorigenesis and metastasis by altering tumor microenvironment factors in pancreatic ductal adenocarcinoma.

ABSTRACT: MUC16, membrane-bound mucin, plays an oncogenic role in pancreatic ductal adenocarcinoma (PDAC). However, the pathological role of MUC16 in the PDAC progression, tumor microenvironment, and metastasis in cooperation with Kras^G12D and Trp53^R172H mutations remains unknown. Deletion of Muc16 with activating mutations Kras^G12D/+ and Trp53^R172H/+ in mice significantly decreased progression and prolonged overall survival in Kras^G12D/+; Trp53^R172H/+; Pdx-1-Cre; Muc16^-/- (KPCM) and Kras^G12D/+; Pdx-1-Cre; Muc16^-/- (KCM), as compared to Kras^G12D/+; Trp53^R172H/+; Pdx-1-Cre (KPC) and Kras^G12D/+; Pdx-1-Cre (KC) mice, respectively. Muc16 knockout pancreatic tumor (KPCM) dis

SUBMITTER: Lakshmanan I 

PROVIDER: S-EPMC9841597 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature