Does Sickle Cell Disease Protect against HIV Infection: A Systematic Review.

ABSTRACT:

Objective

The aim of this systematic review was to investigate whether sickle cell disease (SCD) protects against human immunodeficiency virus (HIV) infection by determining the association between SCD and the incidence and virulence of HIV infection.

Methods

This is a systematic review that used MEDLINE, PubMed, CINAHL, and Academic Search Complete as data sources. Articles describing the relationship of SCD with HIV infection were included in this review. The effect measures were converted to correlation coefficients and synthesized accordingly to examine the putative protective role of SCD against HIV infection. Independent full-text screening and data extraction were conducted on all eligible studies. The risk of bias was assessed using the mixed methods appraisal tool.

SUBMITTER: Nwagha TU 

PROVIDER: S-EPMC9841758 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature