Immunoexpression of stem cell markers SOX-2, NANOG AND OCT4 in ameloblastoma.

ABSTRACT:

Background

Ameloblastoma (AME) is characterized by a locally invasive growth pattern. In an attempt to justify the aggressiveness of neoplasms, the investigation of the role of stem cells has gained prominence. The SOX-2, NANOG and OCT4 proteins are important stem cell biomarkers.

Methodology

To verify the expression of these proteins in tissue samples of AME, dentigerous cyst (DC) and dental follicle (DF), immunohistochemistry was performed and indirect immunofluorescence were performed on the human AME (AME-hTERT) cell line.

Results

Revealed expression of SOX-2, NANOG and OCT4 in the tissue samples and AME-hTERT lineage. Greater immunostaining of the studied proteins was observed in AME compared to DC and DF (p < 0.001).

Conclusions

The presence of bio

SUBMITTER: Martins Balbinot K 

PROVIDER: S-EPMC9841912 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature