Enhancing adoptive T-cell therapy with fucoidan-based IL-2 delivery microcapsules.

ABSTRACT: Adoptive cell therapy (ACT) with antigen-specific T cells is a promising treatment approach for solid cancers. Interleukin-2 (IL-2) has been utilized in boosting the efficacy of ACT. However, the clinical applications of IL-2 in combination with ACT is greatly limited by short exposure and high toxicities. Herein, a complex coacervate was designed to intratumorally deliver IL-2 in a sustained manner and protect against proteolysis. The complex coacervate consisted of fucoidan, a specific IL-2 binding glycosaminoglycan, and poly-l-lysine, a cationic counterpart (FPC²). IL-2-laden FPC² exhibited a preferential bioactivity in ex vivo expansion of CD8⁺T cells over Treg cells. Additionally, FPC² was embedded in pH modulating injectable gel (FPC

SUBMITTER: Jeon EY 

PROVIDER: S-EPMC9842027 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature