Lymphatic channel sheet of polydimethylsiloxane for preventing secondary lymphedema in the rat upper limb model.

ABSTRACT: Secondary lymphedema is a severe complication of cancer treatment, but there is no effective curative method yet. Lymph node dissection and radiation therapy for cancer treatment may lead to secondary lymphedema, which is a chronic disease induced by malfunction of lymphatic flow. The lymphatic channel sheet (LCS) is an artificial micro-fluidic structure that was fabricated with polydimethylsiloxane to maintain lymphatic flow and induce lymphangiogenesis. The structure has two-dimensional multichannels that increase the probability of lymphangiogenesis and allow for relatively easy application. We verified the efficacy of the lymphatic channel sheet through macroscopic and microscopic observation in small animal models, which underwent brachial lymph node dissection and irradiation. The ly

SUBMITTER: Cheon H 

PROVIDER: S-EPMC9842043 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature