Chitosan-based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy.

ABSTRACT: Green chemistry has been a growing multidisciplinary field in recent years showing great promise in biomedical applications, especially for cancer therapy. Chitosan (CS) is an abundant biopolymer derived from chitin and is present in insects and fungi. This polysaccharide has favorable characteristics, including biocompatibility, biodegradability, and ease of modification by enzymes and chemicals. CS-based nanoparticles (CS-NPs) have shown potential in the treatment of cancer and other diseases, affording targeted delivery and overcoming drug resistance. The current review emphasizes on the application of CS-NPs for the delivery of a chemotherapeutic agent, doxorubicin (DOX), in cancer therapy as they promote internalization of DOX in cancer cells and prevent the activity of P-glycoprotein

SUBMITTER: Ashrafizadeh M 

PROVIDER: S-EPMC9842052 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature