Engineering placenta-like organoids containing endogenous vascular cells from human-induced pluripotent stem cells.

ABSTRACT: The placenta is an essential organ that maintains the health of both the fetus and its mother. Understanding the development of human placenta has been hindered by the limitations of existing animal models and monolayer cell cultures. Models that can recapitulate the essential aspects of human placental multicellular components and vasculature are still lacking. Herein, we presented a new strategy to establish placenta-like organoids with vascular-like structures from human-induced pluripotent stem cells in a defined three-dimensional (3D) culture system. The resulting placenta-like tissue resembles first-trimester human placental development in terms of complex placental components and secretory function. The multicellular tissue was characterized by the inclusion of trophoblasts (cytotro

SUBMITTER: Cui K 

PROVIDER: S-EPMC9842056 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature