Early adversities accelerate epigenetic aging into adulthood: a 10-year, within-subject analysis.

ABSTRACT:

Background

Longitudinal studies are needed to clarify whether early adversities are associated with advanced methylation age or if they actually accelerate methylation aging. This study test whether different dimensions of childhood adversity accelerate biological aging from childhood to adulthood, and, if so, via which mechanisms.

Methods

381 participants provided one blood sample in childhood (average age 15.0; SD = 2.3) and another in young adulthood (average age 23.1; SD = 2.8). Participants and their parents provided a median of 6 childhood assessments (total = 1,950 childhood observations), reporting exposures to different types of adversity dimensions (i.e. threat, material deprivation, loss, unpredictability). The blood samples were assayed to estimate DNA methylatio

SUBMITTER: Copeland WE 

PROVIDER: S-EPMC9842095 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature