Urine podocyte mRNA loss in preterm infants and related perinatal risk factors.

ABSTRACT:

Background

Preterm birth has been identified as a risk factor for development of long-term chronic kidney disease. Podocyte loss has been reported to contribute to this process in preterm animal models. However, details about podocyte loss in preterm infants and related perinatal risk factors have not been well clarified.

Methods

Forty full-term infants and 106 preterm infants were enrolled. Urine samples were collected from full-term infants within 4-7 days of birth and preterm infants at 37-40 weeks of corrected age. Levels of urine podocin mRNA, urine protein (UP), and urine microalbumin (UMA) were measured, and the relationship between these markers was evaluated. Clinical information in these infants was collected, and potential correlates that may lead to increased pod

SUBMITTER: Gao Q 

PROVIDER: S-EPMC9842585 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature