The impact of agarose immobilization on the activity of lytic Pseudomonas aeruginosa phages combined with chemicals.

ABSTRACT: The implementation of non-traditional antibacterials is currently one of the most intensively explored areas of modern medical and biological sciences. One of the most promising alternative strategies to combat bacterial infections is the application of lytic phages combined with established and new antibacterials. The presented study investigates the potential of agarose-based biocomposites containing lytic Pseudomonas phages (KT28, KTN4, and LUZ19), cupric ions (Cu²⁺), strawberry furanone (HDMF), and gentamicin (GE) as antibacterials and anti-virulent compounds for novel wound dressings. Phages (KT28, KTN4, LUZ19, and triple-phage cocktail) alone and in combination with a triple-chemical mixture (Cu + GE + HDMF) when applied as the liquid formulation caused a significant bacte

SUBMITTER: Dorotkiewicz-Jach A 

PROVIDER: S-EPMC9842590 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature