Ontology highlight
ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC9842591 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Zhang Jing J van Dinther Maarten M Thorikay Midory M Gourabi Babak Mousavi BM Kruithof Boudewijn P T BPT Ten Dijke Peter P
Cellular and molecular life sciences : CMLS 20230117 2
Ubiquitin-specific protease (USP)19 is a deubiquitinating enzyme that regulates the stability and function of multiple proteins, thereby controlling various biological responses. The alternative splicing of USP19 results in the expression of two major encoded variants that are localized to the endoplasmic reticulum (ER) (USP19-ER) and cytoplasm (USP19-CY). The importance of alternative splicing for the function of USP19 remains unclear. Here, we demonstrated that USP19-CY promotes TGF-β signalin ...[more]