Exploring the mechanism of active components from ginseng to manage diabetes mellitus based on network pharmacology and molecular docking.

ABSTRACT: A large body of literature has shown that ginseng had a role in diabetes mellitus management. Ginsenosides are the main active components of ginseng. But what ginsenosides can manage in diabetic are not systematic. The targets of these ginsenosides are still incomplete. Our aim was to identify which ginsenosides can manage diabetes mellitus through network pharmacology and molecular docking. To identify the targets of these ginsenosides. In this work, we retrieved and screened ginsenosides and corresponding diabetes mellitus targets across multiple databases. PPI networks of the genes were constructed using STRING, and the core targets were screened out through topological analysis. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed by using the R

SUBMITTER: Li MH 

PROVIDER: S-EPMC9842641 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature