Prognostic costimulatory molecule-related signature risk model correlates with immunotherapy response in colon cancer.

ABSTRACT: Costimulatory molecules can promote the activation and proliferation of T cells and play an essential role in immunotherapy. However, their role in the prognosis of colon adenocarcinoma remains elusive. In this study, the expression data of costimulatory molecules and clinicopathological information of 429 patients with colon adenocarcinoma were obtained from The Cancer Genome Atlas database. The patients were divided into training and verification cohorts. Correlation, Cox regression, and Lasso regression analyses were performed to identify costimulatory molecules related to prognosis. After mentioning the construction of the risk mode, a nomogram integrating the clinical characteristics and risk scores of patients was constructed to predict prognosis. Eventually, three prognostic costimu

SUBMITTER: Huang W 

PROVIDER: S-EPMC9842650 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature