Intravenous fentanyl self-administration in male and female C57BL/6J and DBA/2J mice.

ABSTRACT: The genetic mechanisms underlying fentanyl addiction, a highly heritable disease, are unknown. Identifying these mechanisms will lead to better risk assessment, early diagnosis, and improved intervention. To this end, we used intravenous fentanyl self-administration to quantify classical self-administration phenotypes and addiction-like fentanyl seeking in male and female mice from the two founder strains of the BXD recombinant inbred mouse panel (C57BL/6J and DBA/2J). We reached three primary conclusions from these experiments. First, mice from all groups rapidly acquired intravenous fentanyl self-administration and exhibited a dose-response curve, extinction burst, and extinction of the learned self-administration response. Second, fentanyl intake (during acquisition and dose response) a

SUBMITTER: Leonardo M 

PROVIDER: S-EPMC9842734 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature