Uterine epithelial Gp130 orchestrates hormone response and epithelial remodeling for successful embryo attachment in mice.

ABSTRACT: Leukemia inhibitory factor (LIF) receptor, an interleukin 6 cytokine family signal transducer (Il6st, also known as Gp130) that is expressed in the uterine epithelium and stroma, has been recognized to play an essential role in embryo implantation. However, the molecular mechanism underlying Gp130-mediated LIF signaling in the uterine epithelium during embryo implantation has not been elucidated. In this study, we generated mice with uterine epithelium specific deletion of Gp130 (Gp130 ecKO). Gp130 ecKO females were infertile due to the failure of embryo attachment and decidualization. Histomorphological observation revealed that the endometrial shape and embryo position from Gp130 ecKO were comparable to those of the control, and uterine epithelial cell proliferation, whose attenuation is

SUBMITTER: Namiki T 

PROVIDER: S-EPMC9842754 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature