Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis.

ABSTRACT: While immunotherapy has emerged as a breakthrough cancer therapy, it is only effective in some patients, indicating the need of alternative therapeutic strategies. Induction of cancer immunogenic cell death (ICD) is one promising way to elicit potent adaptive immune responses against tumor-associated antigens. Type I interferon (IFN) is well known to play important roles in different aspects of immune responses, including modulating ICD in anti-tumor action. However, how to expand IFN effect in promoting ICD responses has not been addressed. Here we show that depletion of ubiquitin specific protease 18 (USP18), a negative regulator of IFN signaling, selectively induces cancer cell ICD. Lower USP18 expression correlates with better survival across human selected cancer types and delays canc

SUBMITTER: Arimoto KI 

PROVIDER: S-EPMC9842760 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature