Molecular epidemiology and genomic insights into the transmission of carbapenem-resistant NDM-producing Escherichia coli.

ABSTRACT: Escherichia coli is a leading cause of nosocomial infections. Carbapenem-resistant E. coli (CREC), which has been frequently isolated in recent years because of the widespread use of carbapenems, poses a significant challenge to clinical anti-infection treatment. In this study, a total of 27 CREC strains were identified from a set of 795 E. coli isolates collected over a two-year period from a tertiary hospital in China. Whole-genome sequencing revealed that 17 strains carried the bla _NDM-5 gene, 5 strains carried the bla _NDM-1 gene, 1 strain carried the bla _NDM-7 gene, and the remaining 4 strains carried the bla _KPC-2 gene. All 23 NDM-producing E. coli strains were resistant to all antibiot

SUBMITTER: Xu J 

PROVIDER: S-EPMC9842800 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature