Childhood trauma, earlier pubertal timing, and psychopathology in adolescence: The role of corticolimbic development.

ABSTRACT: Earlier pubertal development appears to be one pathway through which childhood trauma contributes to psychopathology in adolescence. Puberty-related changes in neural networks involved in emotion processing, namely the amygdala-medial prefrontal (mPFC) circuit, may be a potential mechanism linking trauma and adolescent psychopathology. Our participants were 227 youth between 10 and 13 years of age who completed assessments of threat and deprivation-related experiences of adversity, pubertal stage, and internalizing and externalizing symptoms. A subset (n = 149) also underwent a functional MRI scan while passively viewing fearful and calm faces. Potential mechanisms linking childhood trauma with psychopathology, encompassing earlier pubertal timing and neural response to aversive stimuli we

SUBMITTER: Colich NL 

PROVIDER: S-EPMC9842860 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature