Effect of HIV infection and antiretroviral therapy initiation on genome-wide DNA methylation patterns.

ABSTRACT:

Background

Previous epigenome-wide association studies have shown that HIV infection can disrupt the host DNA methylation landscape. However, it remains unclear how antiretroviral therapy (ART) affects the HIV-induced epigenetic modifications.

Methods

184 individuals with HIV from the NEAT001/ANRS143 clinical trial (with pre-ART and post-ART samples [96 weeks of follow-up]) and 44 age-and-sex matched individuals without HIV were included. We compared genome-wide DNA methylation profiles in whole blood between groups adjusting for age, sex, batch effects, and DNA methylation-based estimates of leucocyte composition.

Findings

We identified 430 differentially methylated positions (DMPs) between HIV+ pre-ART individuals and HIV-uninfected controls. In participants with HI

SUBMITTER: Esteban-Cantos A 

PROVIDER: S-EPMC9842861 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature